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- 3Monoamine oxidase
- 2Amino acids
- 2Experimental autoimmune encephalomyelitis
- 2Multiple Sclerosis
Amino acid and biogenic amine concentrations during experimental autoimmune encephalomyelitis and the disease-modifying effects of phenelzine treatmentDownload
The project described in this thesis began with a broad analysis of the changes to amino acid and biogenic amine concentrations in the central nervous system (CNS) during experimental autoimmune encephalomyelitis (EAE) in mice, an animal model of Multiple Sclerosis (MS). That study identified...
Central nervous system plasticity associated with pain in a mouse model of multiple sclerosis, and the antinociceptive effects of the antidepressant phenelzineDownload
Multiple sclerosis (MS) is a chronic, progressive disease that involves neuroinflammation, demyelination, and neurodegeneration within the central nervous system (CNS). While loss of motor function and paralysis are considered the primary clinical consequences of MS, the disease is also...
Investigating the Effects of N2-Acetylphenelzine in the Sexes in Experimental Autoimmune EncephalomyelitisDownload
Chronic pain is a highly prevalent symptom in Multiple Sclerosis (MS) and affects approximately half of patients at some stage of the disease. MS affects women more frequently than men and neuropathic pain is also reported as more severe, and frequent, in females with the disease. The underlying...
Neurochemical and neuroprotective aspects of phenelzine and its active metabolite B-phenylethylidenehydrazineDownload
Phenelzine (PLZ) is a monoamine oxidase (MAO) inhibitor that also inhibits the activity of GABA-transaminase (GABA-T), causing significant and long-lasting increases in brain GABA levels. Inhibition of MAO prior to PLZ administration has been shown to prevent the GABAergic effects of the drug,...
Phenelzine is a monoamine oxidase (MAO) inhibitor that has been used for the treatment of depression and anxiety disorders since the 1960s. In recent years, there has been renewed interest in this drug following reports of its neuroprotective properties in animal models of cerebral ischemia,...
The Antidepressant/Antipanic/Neuroprotective Drug Phenelzine: Neuropharmacological and Drug Metabolism StudiesDownload
Phenelzine (PLZ) is a monoamine oxidase (MAO)-inhibiting antidepressant with anxiolytic and neuroprotective properties. Metabolites of PLZ were investigated in rat brain. Levels of phenylacetic acid (PAA) and β-phenylethylamine (PEA) were found to be elevated after administration of PLZ and PEH...