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- 1ATP-sensitive potassium channel
- 1Biophysics
- 1COVID-19
- 1Chronic pain
- 1Electrophysiology
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Spring 2012
Voltage-gated potassium (Kv) channels regulate the flow of potassium ions across the cell membrane of nerves and muscles. Proper functioning of these and other voltage-gated ion channels is critical for an animal to sense the environment and respond quickly to stimuli. Dysfunctional Kv channels,...
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Spring 2016
This thesis examines the cellular basis of the acute (<1 hour) anti-allodynic actions of the clinically-approved neuropathic pain drug gabapentin (GBP) in rats at the level of the spinal dorsal horn and primary somatosensory cortex. Although the clinical effectiveness of the alpha-2-delta (α2δ)...
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Characterization of eNOS-based Platelets Subpopulations in COVID-19 and the Impact of Platelet α-Granule Contents on Cancer Cell PD-L1
DownloadFall 2024
Thrombosis significantly complicates numerous diseases that have inflammatory components. This condition, characterized by the formation of blood clots within blood vessels, can exacerbate a range of health issues, from cardiovascular diseases to systemic infections like COVID-19, and even...
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Fall 2018
Epilepsy is among the most common neurological diseases, but approximately 30% of epileptics are unresponsive to available drugs, and many more suffer significant side effects. One reason for the persisting large fraction of drug-resistant or drug-intolerant patients may be that most drug...
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Spring 2011
The cardiac sodium-calcium exchanger (NCX) is an important membrane protein which regulates cellular calcium necessary for the optimal contractile function of the heart. NCX has become a focal point in ischemic heart disease (IHD) research as evidence suggests that reactive oxygen species (ROS)...
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Spring 2019
Type 2 diabetes mellitus (T2DM) is characterized by peripheral insulin resistance and an insufficiency of insulin secretion from the pancreatic β cell. The incidence of T2DM is rising worldwide at an alarming rate. Increased prevalence of obesity is a major contributor to this rise in T2DM...
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Sex Differences in Central Nervous System Plasticity and Pain in Experimental Autoimmune Encephalomyelitis
DownloadSpring 2019
Multiple sclerosis (MS) is a neurodegenerative autoimmune disease with many known structural and functional changes in the central nervous system (CNS). A well-recognized, but poorly understood, complication of MS is chronic pain. Little is known regarding the influence of sex on the development...