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Synthetic lethal targeting of polynucleotide kinase/phosphatase and its potential role in directed cancer therapies
DownloadFall 2012
Synthetic lethality arises when simultaneous disruption of two non-essential, non-allelic genes in the same cell causes lethality. This phenomenon has been shown to occur between proteins involved in DNA repair and much attention to date has focused on poly(ADP-ribose) polymerase and the BRCA...
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Fall 2019
Breast cancer (BCa) is the most frequently diagnosed cancer in women worldwide. Treatment strategies often target hormone receptors on breast cancer cells. Triple-negative breast cancer (TNBC) is a BCa subtype where estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth...