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Synthetic lethal targeting of polynucleotide kinase/phosphatase and its potential role in directed cancer therapies
DownloadFall 2012
Synthetic lethality arises when simultaneous disruption of two non-essential, non-allelic genes in the same cell causes lethality. This phenomenon has been shown to occur between proteins involved in DNA repair and much attention to date has focused on poly(ADP-ribose) polymerase and the BRCA...
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