This decommissioned ERA site remains active temporarily to support our final migration steps to https://ualberta.scholaris.ca, ERA's new home. All new collections and items, including Spring 2025 theses, are at that site. For assistance, please contact erahelp@ualberta.ca.
Search
Skip to Search Results- 5PNKP
- 2DNA repair
- 1Colorectal Cancer
- 1Computational modeling
- 1DNA Repair
- 1DNA Single Strand Break Repair
-
Evaluating the consequences of polynucleotide kinase/phosphatase (PNKP) mutations in neurological diseases
DownloadSpring 2022
Genomic stability is extremely important for developing or maintaining normal neurological functions, as the nervous system is constantly suffering from endogenous DNA damage. To maintain such stability, living cells are protected by several different DNA repair pathways. Polynucleotide...
-
Spring 2019
Cancer remains a challenging disease to tackle. The heterogeneity and evolution of the disease necessitates the development of diverse approaches to treat cancer. In this thesis, two different approaches have been undertaken to address this issue. The first aim was to activate the master tumor...
-
Fall 2015
The repair of damaged DNA is critically important for maintaining a stable cellular environment to ensure proper and high fidelity segregation and transmission of genetic information from one generation to the next. DNA can be subjected to many forms of DNA damage that are handled by dedicated...
-
Spring 2022
Targeting DNA repair enzymes has attracted much attention in recent years to overcome the therapeutic resistance in cancer therapy. Inhibition of DNA repair enzymes can be used to make cancer cells sensitive to the DNA damaging effect of ionizing radiation or chemotherapy. In addition, the...
-
Role of human polynucleotide kinase/phosphatase (PNKP) in nuclear and mitochondrial DNA repair
DownloadFall 2015
DNA is continuously under stress from the insults inflicted by both endogenous and exogenous agents. These agents include endogenous reactive oxygen species (ROS), ionizing radiation (IR) and many common chemotherapeutic drugs, which can inflict a plethora of DNA lesions including abasic sites,...