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Evaluating the consequences of polynucleotide kinase/phosphatase (PNKP) mutations in neurological diseases
DownloadSpring 2022
Genomic stability is extremely important for developing or maintaining normal neurological functions, as the nervous system is constantly suffering from endogenous DNA damage. To maintain such stability, living cells are protected by several different DNA repair pathways. Polynucleotide...
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Spring 2019
Cancer remains a challenging disease to tackle. The heterogeneity and evolution of the disease necessitates the development of diverse approaches to treat cancer. In this thesis, two different approaches have been undertaken to address this issue. The first aim was to activate the master tumor...
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Fall 2015
The repair of damaged DNA is critically important for maintaining a stable cellular environment to ensure proper and high fidelity segregation and transmission of genetic information from one generation to the next. DNA can be subjected to many forms of DNA damage that are handled by dedicated...
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Role of human polynucleotide kinase/phosphatase (PNKP) in nuclear and mitochondrial DNA repair
DownloadFall 2015
DNA is continuously under stress from the insults inflicted by both endogenous and exogenous agents. These agents include endogenous reactive oxygen species (ROS), ionizing radiation (IR) and many common chemotherapeutic drugs, which can inflict a plethora of DNA lesions including abasic sites,...