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Subject: PKD2L1

  • Function and Regulation of PKD2 and PKD2L1

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    Spring 2013

    Yang, Jungwoo

    Autosomal dominant polycystic kidney disease (ADPKD) is an inherited genetic disorder, inducing cysts in kidney, liver and pancreas. It is caused by pathogenic mutations in the PKD1 or PKD2 gene encoding PKD1 or PKD2 respectively. Cellular abnormalities in ADPKD include cell over-proliferation...

  • Functional Characterization of the TRP-Type Channel PKD2L1

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    Fall 2015

    Hussein, Shaimaa A

    Polycystic kidney disease (PKD) protein 2 Like 1 (PKD2L1), also called transient receptor potential polycystin-3 (TRPP3), regulates Ca2+-dependent hedgehog signalling in primary cilia, intestinal development and sour tasting but with an unclear mechanism. PKD2L1 is a Ca2+-permeable cation channel...

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