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Investigations of interactions between membrane and PEI/siRNA nanoparticles and their implication for non-viral gene delivery
DownloadSpring 2021
Cell entry of polynucleotide-based therapeutic agents can be promoted by nanoparticle (NP) mediated delivery. This dissertation investigates membrane penetration of polynucleotide NPs, using mainly computational approaches, accompanied by some experiments. Major emphasis was placed on...
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Spring 2015
Protein silencing by small interfering RNA (siRNA) is a promising treatment strategy for cancer as over-expression of proteins is largely responsible for cancer cells’ infinite proliferation, evasion of cell death and multi-drug resistance. However, siRNAs require a carrier as their biological...