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Fall 2024
The stochastic diversification of the T cell receptor (TCR) carries with it both the potential for recognizing virtually infinite foreign peptides, but also the potential for the erroneous recognition of self-peptides, which represents a threat of autoimmunity. During development in the thymus, T...
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The role of programmed death-1 (PD-1) expression in the negative selection of T lymphocytes
DownloadSpring 2011
The immune system must be able to mount a response against pathogens and transformed cells while remaining tolerant to healthy host tissue. A key process for ensuring this self-tolerance is the negative selection of self-reactive thymocytes. Expression of Programmed Death-1 (PD-1), a...