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A Novel Association Between Primary Biliary Cholangitis and Idiopathic Pulmonary Arterial Hypertension
DownloadFall 2020
Background and Hypothesis Idiopathic Pulmonary Arterial Hypertension (IPAH) and Primary Biliary Cholangitis (PBC) are both rare diseases that are progressive and may be fatal when left untreated. Furthermore, mitochondrial dynamics are fundamental to the pathogenesis of both conditions. An...
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Chronic Fatigue Mechanisms in Autoimmune Diseases: Lessons from Primary Biliary Cholangitis and Systemic Sclerosis
DownloadFall 2023
Systemic sclerosis (SSc) is an autoimmune disease affecting the body's connective tissues, resulting in progressive fibrosis and vasculopathy. In some cases, individuals with SSc may also develop primary biliary cholangitis (PBC), another autoimmune disease characterized by damage to their...
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Investigating Primary Biliary Cholangitis for a Human Betaretrovirus Superantigen signature
DownloadSpring 2022
Primary Biliary Cholangitis (PBC) is an idiopathic autoimmune disease characterized by destruction of small hepatic bile ducts and presence of antimitochondrial antibodies (AMA). A Human Betaretrovirus (HBRV) sharing 91-99% sequence similarity with the Mouse Mammary Tumor virus has been...