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Hsp90 and its co-chaperones regulate the activity of human Argonaute2 in RNA-mediated silencing pathways
DownloadFall 2011
The potent ability of small, double-stranded RNAs to silence gene expression was initially reported 1998, sparking revolutions in molecular biology and genetics. Since then, intensive research into the mechanism of RNA-mediated silencing has implicated the machinery of this pathway in the...
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The Drosophila GW protein, a posttranscriptional gene regulator that influences progression through mitosis
DownloadSpring 2010
Regulation of mRNA translation and stability can occur in cytoplasmic compartments known as mRNA processing bodies or P bodies. These compartments contain factors that function in multiple mRNA regulatory pathways and are thought to be centres for coordinating the action of these pathways. One...