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Active-β-catenin (ABC) Transcriptional Activity is Associated with and may Promote Invasive Phenotype in Osteosarcoma (OS)
DownloadFall 2021
Osteosarcoma (OS) is an aggressive primary malignancy of the bone with the greater proportion of affected individuals being in the 10-30 years age range. The 5-year relative survival rates for patients with localized OS is 77% and 27% for patients with metastatic cancer. 15-20% of patients on...
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Development of three dimensional and in vivo modelling systems for the overexpression of Active-β-catenin in osteosarcoma
DownloadFall 2023
Introduction: Osteosarcoma (OS) is a primary bone malignancy most commonly found in children and adolescents. The 5-year survival rate for OS is 60%, which decreases to 27% when distant metastases are present. Currently no tests are available to identify those patients at risk of metastatic...
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Osteosarcoma (OS) progression is associated with increased nuclear levels and transcriptional activity of Active-β-catenin (ABC)
DownloadSpring 2019
Osteosarcoma (OS) is an aggressive primary bone malignancy having peak incidence in children and young adults <25 years of age. Outcome remains poor for most patients with metastatic disease which develops in 1 of every 5 cases. However, despite the use of multimodal chemotherapeutic and surgical...
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Spring 2016
Osteosarcoma (OS) is the most common primary bone malignancy with a high incidence in children and adolescents. Current treatment strategies (surgery and adjuvant chemotherapy) has improved the overall survival rate of patients with primary OS. However, the survival rate of patients with...