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- 1Anti-malarial
- 1Boron
- 1Cladosporin
- 1Conjugation
- 1Dess-Martin Periodinane Oxidative Rearrangement
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Syntheses of Probes for the Elucidation of Biosynthetic Pathways and Interactions of Natural Products
DownloadFall 2018
A new platform for the semi-synthetic preparation of a known nanomolar inhibitor of the Plasmodium falciparum lysyl-tRNA synthetase, cladosporin, from Cladosporium cladosporioides and its analogues was developed. Our work has shown that it is produced biosynthetically by a highly reducing (HR)...
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Synthesis, Structure and Properties of a Novel “Frustrated” Benzoxaborole and the Role of Boron in Bioconjugation
DownloadSpring 2020
Chapter 2 describes an optimized 7-step successful synthesis of a first of its kind permanently open-form ortho-hydroxyalkyl arylboronic acid, otherwise known as a “frustrated benzoxaborole”, with a columnless purification and complete structure elucidation. This novel compound is completely...