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Folding of biomolecules is an important problem in structural biology. The physical folding can be projected as a diffusive search over an energy landscape whose dimensions scale by all the internal degrees of freedom which a biomolecule possesses. To explore this idea, folding is studied from...
High resolution optical tweezers for single molecule studies of hierarchical folding in the pbuE riboswitch aptamerDownload
Riboswitches are gene regulatory elements found in messenger RNA that function by changing structure upon the binding of a ligand to an aptamer domain. Single adenine-binding pbuE riboswitch aptamer RNAs were unfolded and refolded co-transcriptionally using optical tweezers for single molecule...
Intrinsically disordered proteins (IDPs) represent a large subpopulation of the proteome, and are characterized by high structural plasticity and a predisposition to aggregate. These aggregates can accumulate inside or outside the cell, often forming amyloid plaques that are implicated in a...
Prion diseases, are associated with the misfolded form of the prion protein (PrPSc). The prion protein (PrP) has a unique means of transferring infectious diseases, based on a misfolded conformation. However, the mechanism of formation of PrPSc remains unclear owing to difficulties in defining...
The formation of an abnormal form of proteins in cells can cause aggregation and neurodegenerative pathology, such as Alzheimer’s, Parkinson’s and prion diseases, which affects both humans and animals. Nowadays, the understanding of the mechanism of prion misfolding and propagation, including...