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Spring 2014

Bemile, Esther N

Despite significant efforts to inform and educate consumers across North America on healthy eating through “easy to follow” dietary guidelines, diet related non-communicable diseases are on the ascendancy. The objective of this thesis is to use the National Health and Nutrition Examination Survey...

Fall 2024

Vasilev, Boyan S

Background: Dyslipidemia is a common characteristic in both diabetes and obesity, due in part to elevated triglyceride (TG)-rich very-low density lipoprotein (VLDL-TG) secretion from the liver. Excessive levels and/or action of glucocorticoids (GCs) is also observed in these metabolic diseases...

Spring 2022

Cardoso, Miguel

Background: In metabolic disease statues, such as diabetes and obesity, dyslipidemia is characterized by a dysregulation of lipid homeostasis, due in part to elevated triglyceride (TG)-rich very low-density lipoprotein (VLDL-TG) production and secretion by the liver. Further, these metabolic...

Fall 2013

Ferland, Adam R

Childhood obesity has risen dramatically over recent decades in Canada, attributed largely to increasingly obesogenic environments. Our understanding of obesity now recognizes its complex ecological etiology, yet life skills – critical to how children engage with their surroundings – have been...

Spring 2011

Rueda-Clausen, Christian Federico

Cardiovascular and metabolic diseases are still the primary cause of death and disability in modern society. Although genetic factors play a fundamental role in the development of these chronic conditions, the remarkable variability in an individual’s susceptibility to develop these pathologies...

Fall 2015

Li, Jiaying

Although genetic factors, diet choices and sedentary lifestyle have long been considered main risk contributors for obesity and diabetes mellitus, years of study show that these factors cannot fully explain the increasing rate of worldwide metabolic disease. Epidemiological studies in recent...

Fall 2019

Krysa, Jacqueline

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Abnormal levels of circulating lipids (dyslipidemia) is a well-known risk factor for CVD. Traditionally, fasting lipids, inclusive of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC), have...

Fall 2018

Aburasayn, Hanin

As the rate of obesity is increasing among children born to obese parents, our aim was to delineate how parental obesity promotes obesity risk in the offspring. A secondary aim was to determine if offspring born to obese parents would also be at risk of developing obesity-related metabolic...

Fall 2024

Browne, Nadia E.

Background. One in three Canadian children and adolescents are living with obesity, so evidence-based, effective interventions for managing adolescent obesity are critically important. Motivation (i.e., desire and drive for change) and readiness to change (i.e., capability for change) are...

Fall 2024

Zhu, Mengyi

Obesity and associated insulin resistance (IR) represent a significant global health burden. Emerging evidence suggests that obesity is accompanied by impaired adaptive immunity. B cells contribute significantly to adaptive immunity, and the dysregulation of B cell function in obese individuals...