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Biochemical Studies on the Mechanism of Action of Remdesivir and Other Nucleotide Analog Polymerase Inhibitors during the COVID-19 Pandemic
DownloadFall 2024
Several disease-causing RNA virus families, capable of infecting humans, remain a significant global health threat due to the lack of effective medical countermeasures. This was perhaps best exemplified early in the COVID-19 pandemic when spread of severe acute respiratory syndrome coronavirus 2...
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The mechanism of action of cidofovir and (S)-9-(3-hydroxy-2-phosphonomethoxypropyl)adenine against viral polymerases
DownloadFall 2009
The nucleoside phosphonates cidofovir (CDV) and (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine [(S)-HPMPA] are analogs of dCMP and dAMP, respectively. Collectively these drugs are effective inhibitors of a wide range of DNA viruses, RNA viruses, and retroviruses. Because they are nucleotide...