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- 16-Mercaptopurine
- 1Acute Lymphoblastic Leukemia
- 1Equilibrative Nucleobase Transporter 1
- 1HPLC
- 1Mouse Plasma
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Function and Regulation of Equilibrative Nucleobase Transporter 1 in Acute Lymphoblastic Leukemia
DownloadFall 2024
Background: 6-Mercaptopurine (6-MP) is a purine nucleobase analog used for the treatment of acute lymphoblastic leukemia (ALL), inflammatory bowel disease, and other disorders. 6-MP is primarily used in ALL, the most common childhood cancer. Enzymes involved in 6-MP metabolism have been shown to...
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High Performance liquid Chromatography Analysis of Nucleosides and Nucleobases in Mouse Plasma and Xenopus oocytes
DownloadFall 2017
In humans, there are three members of the cation-coupled concentrative nucleoside transporter CNT (SLC28) family, hCNT1-3: hCNT1 is selective for pyrimidine nucleosides but also transports adenosine, hCNT2 transports purine nucleosides and uridine, and hCNT3 transports both pyrimidine and purine...