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A role for the nuclear transport machinery in supporting positive-strand RNA virus infection and in regulating innate immune responses
DownloadSpring 2015
In eukaryotic cells, the genetic material is encapsulated in a double lipid membrane layer to form the nuclear compartment. This double membrane layer, termed the nuclear envelope, is fenestrated by pores, which are occupied by proteinaceous gateway structures termed nuclear pore complexes...
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Spring 2015
Nuclear pore complexes (NPCs) form aqueous portals in the nuclear envelope (NE) and are the sole sites for molecular exchange between nuclear and cytoplasmic compartments. While ions, small metabolites and molecules under ~40 kDa can freely passage through NPCs, most macromolecular transport...