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Characterizing the mode of action of super long-acting beta2-adrenergic receptor agonists: A more effective therapeutic for Parkinson's disease.
DownloadFall 2016
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by a loss of dopaminergic neurons in the Substantia nigra (SN) resulting in hypokinetic motor movements. The long-acting beta2-adrenergic receptor (β2-AR) agonist salmeterol has been shown to be neuroprotective in animal...
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Spring 2010
Microglia, the resident immune cells of the central nervous system (CNS), become activated in response to danger signals given out by other cells when homeostasis has been disturbed. Microglial activation is a multifaceted phenomenon that includes numerous distinct phenotypes. The type of...
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Mechanism of beta 2 adrenergic receptor (β2AR) agonist in regulation of inflammation in Parkinson’s disease
DownloadFall 2019
Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterized by degeneration of dopaminergic neurons (DA-neurons) which are primarily present within a region of the brain called as substantia nigra (SN). Several studies suggest that the etiology of the PD includes...
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Sex Differences in Central Nervous System Plasticity and Pain in Experimental Autoimmune Encephalomyelitis
DownloadSpring 2019
Multiple sclerosis (MS) is a neurodegenerative autoimmune disease with many known structural and functional changes in the central nervous system (CNS). A well-recognized, but poorly understood, complication of MS is chronic pain. Little is known regarding the influence of sex on the development...