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- 3Nazarov reaction
- 2Alternative Nazarov reaction
- 2Interrupted Nazarov reaction
- 1Allylic alcohol transposition
The five-membered carbocyclic framework is a prevailing structural motif found in natural products and bioactive compounds. Over the years, the Nazarov reaction has been continuously refined as a versatile protocol to access cyclopentanoid products. In this dissertation, several projects built...
This dissertation expands the scope and understanding of the Nazarov electrocyclization and interception of the reactive cyclopentenyl cation intermediate that is formed though a 4π electrocyclization of a pentadienyl cation. An intermolecular process for interrupting the Nazarov is discussed....
5-Membered carbocycles are ubiquitous in natural products and synthetic drugs. Methods of generating them are therefore valuable, and the ability to do so in a stereospecific and enantioselective manner while making considerable gains in molecular complexity with additional incorporation of...