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Investigations of interactions between membrane and PEI/siRNA nanoparticles and their implication for non-viral gene delivery
DownloadSpring 2021
Cell entry of polynucleotide-based therapeutic agents can be promoted by nanoparticle (NP) mediated delivery. This dissertation investigates membrane penetration of polynucleotide NPs, using mainly computational approaches, accompanied by some experiments. Major emphasis was placed on...
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Fall 2022
Throughout this thesis, methods for tailoring nanoparticles are broadly discussed and demonstrated experimentally. The main objective of this work was to help bridge the gap between fundamental materials science and global concerns by contributing to the development of functional nanomaterial...