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Fall 2014
The vast majority of anaplastic lymphoma kinase positive anaplastic large cell lymphoma (ALK+ALCL) tumors carry the genetic translocation t(2;5)(p23;q35), leading to production of the constitutively active fusion tyrosine kinase NPM-ALK. NPM-ALK expression and its potent transformative properties...
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The Role of Oncogenic Tyrosine Kinase NPM-ALK in Anaplastic Large Cell Lymphoma Pathobiology
DownloadFall 2012
Anaplastic lymphoma kinase expressing anaplastic large cell lymphoma (ALK+ALCL) is an aggressive type of T/null cell lymphoma that mainly affects children and young adults and represents up to 40% of non-Hodgkin’s lymphoma in children. These lymphomas are characterized by the abnormal chromosomal...