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Fall 2014
The vast majority of anaplastic lymphoma kinase positive anaplastic large cell lymphoma (ALK+ALCL) tumors carry the genetic translocation t(2;5)(p23;q35), leading to production of the constitutively active fusion tyrosine kinase NPM-ALK. NPM-ALK expression and its potent transformative properties...
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Fall 2019
Forkhead Box M1 (FOXM1) is a transcription factor which belongs to the evolutionary conserved Forkhead protein family. FOXM1 has been implicated in the pathogenesis of several solid and hematologic cancers. In this study, the significance of FOXM1 in NPM-ALK-positive anaplastic large cell...