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- 1Creatine kinase
- 1Extracellular regulated kinase 1/2
- 1Gene expression
Sustained acidosis and phenylephrine activate the myocardial Na+/H+ exchanger through phosphorylation of Ser770 and Ser771Download
The mammalian Na+/H+ exchanger isoform 1 (NHE1) is a ubiquitously expressed membrane protein that regulates myocardial intracellular pH. Inhibition of NHE1 prevents hypertrophy and reduces ischemia-reperfusion (I/R) injury in animal models. To understand the regulation of NHE1 in the myocardium...