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Mammalian and Saccharomyces cerevisiae ER-mitochondria contact site regulation by small Rab GTPases and ER folding assistants
DownloadFall 2021
Membrane-bound organelles allow eukaryotes to compartmentalize components and processes in a highly organized manner. Organelles can communicate with one another through membrane contact sites (MCS): membrane appositions 10-50nm apart. MCS were not widely accepted as bona fide sites of organelle...
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Spring 2023
The endoplasmic reticulum (ER) mitochondria-associated membrane (MAM), or the contact site between the ER and mitochondria, serves a control station for mitochondrial metabolism. Here, chaperones and enzymes control the Ca2+ flux between the two organelles, thereby altering energy production via...