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Role of matrix metalloproteinase-2 in sarcoplasmic reticulum dysfunction during myocardial ischemia-reperfusion injury
DownloadSpring 2019
Matrix metalloproteinase-2 (MMP-2) is an intra- and extra-cellular protease which is activated during myocardial ischemia-reperfusion (IR) injury by reactive oxygen and nitrogen species, namely peroxynitrite. Upon its activation, MMP-2 impairs cardiac contractility by cleaving sarcomeric and...
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