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Mammalian and Saccharomyces cerevisiae ER-mitochondria contact site regulation by small Rab GTPases and ER folding assistants
DownloadFall 2021
Membrane-bound organelles allow eukaryotes to compartmentalize components and processes in a highly organized manner. Organelles can communicate with one another through membrane contact sites (MCS): membrane appositions 10-50nm apart. MCS were not widely accepted as bona fide sites of organelle...
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Fall 2013
Ortiz Sandoval, Carolina Guadalupe
The ER mitochondria-associated membrane (MAM) is a hub for many calcium-mediated processes required for cell survival, including apoptosis, autophagy, and ATP production. In this thesis, we identified and characterized the interaction between MAM-enriched Rab32 and its effector Drp1, a master...