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The heart requires an uninterrupted supply of fuels to sustain its physiological function. Fatty acids are the predominant substrates and endogenous triglyceride turnover contributes significantly to fatty acid oxidation. Lipins are cytosolic, bifunctional enzymes involved in both glycerolipid...
A potential therapeutic target in cancer is phospholipase D (PLD), which converts phosphatidylcholine into phosphatidic acid, a lipid second messenger in cell signalling. The lipid phosphate phosphatases are considered to convert PLD-generated phosphatidic acid to diacylglycerol. However, the...