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A path towards better cancer drugs: Modeling interactions between antimitotic agents and tubulin
DownloadFall 2015
Antimitotic agents, a class of cancer chemotherapies, target the tubulin protein in microtubules to suppress microtubule dynamics and affect the segregation of chromosomes during cell division. A variety of antimitotic agents are known, which range in status from clinically-approved agents to...
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An investigation of factors that regulate cytoskeleton in the first mitotic division of the C. elegans embryo
DownloadFall 2017
Microtubule dynamics is regulated by naturally occurring microtubule-associated proteins occurring in the cellular environment as well as by natural and synthetic compounds. These compounds target the microtubule cytoskeleton and serve as anti-mitotic drugs. Therefore, microtubules continue to be...
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Breaking New Ground with the Suzuki-Miyaura Reaction: Stereoselective Cross-Couplings of 1,1-Diboronyl Alkanes
DownloadFall 2015
Synthetic organic chemistry is an area that has seen incredible growth through the years. The level of molecular complexity that can be achieved through available synthetic methods today is remarkable. Still, as the field continues to progress, increasing focus is being placed upon the strategic...
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Delving into Group 16 – Increasing the Accessibility and Understanding the Optoelectronic Properties of Tellurophenes
DownloadFall 2020
This Thesis describes the investigation of 5-membered heterocycles that contain the heavy atom tellurium (Te), termed tellurophenes, as light emitting materials or the active (light absorbing) component in organic photovoltaics. A particular focus was placed on developing new routes to synthesize...
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Fall 2011
The sequestering of alkali and alkaline earth cations by host structures (ethylenediamine tetraacetate, 18-crown-6, and hexaaza[18]annulene) was accomplished using density functional theory and either all electron or model core potential basis sets. The sequestering of alkali and alkaline earth...
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Preparation of Polysubstituted Pyrans Toward the Synthesis of Biologically Active Compounds
DownloadSpring 2016
Polyfunctionalized pyrans are among the most common structures in bioactive molecules. Based on the ubiquity of the pyran framework in natural and synthetic molecules, there is a need to develop more efficient methods of synthesizing and functionalizing the pyran motif. Due to recent interest in...