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Exploring New Avenues in Islet Transplantation: Localized Immune Modulations with Rapamycin-Eluting Microparticles
DownloadFall 2024
Islet transplantation (ITx) is an effective means to restore physiologic glycemic regulation in those living with type 1 diabetes; however, lifelong systemic immunosuppression required to subvert the immune response remains a major barrier to patient inclusion. While these drug therapies delay...
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Neonatal Porcine Islet Xenotransplantation: Non-invasive in vivo imaging and basic islet biology
DownloadFall 2022
Islet transplantation has been proven as a successful clinical therapy for diabetes; however, its widespread use is limited by multiple factors including a shortage of human donors, the need for long term immunosuppression and difficulty with graft monitoring post transplantation. Pig islet...
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Fall 2022
Islet cell transplantation is an effective method to treat type 1 diabetes mellitus, however, significant barriers currently exist preventing its implementation as the gold standard therapy. Of note, cell death in the acute post-transplant period accounts for loss of up to 80% of newly...
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The BETA-2 Score: a Tool for Assessing Beta Cell Function in Clinical Islet Transplantation and Type 1 Diabetes Intervention Trials
DownloadFall 2017
Preservation of beta cell function is integral to clinical islet transplantation (CIT) and in the development of treatments which halt the progression of type 1 diabetes (T1D). Outcome assessment remains difficult in both fields as the preservation of beta cell function and maintenance of glucose...