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Clinical and Translational Studies Advancing Clinical Implementation of Stem Cell-Derived Islet Transplantation
DownloadSpring 2024
Twenty-years ago Shapiro et al. revolutionized islet transplantation (ITx), realizing the potential for a cell-based diabetes treatment. Despite improvements, ITx remains restricted by organ donor limitations and immunosuppression. Stem cell (SC)-derived ITx (SC Tx) could eliminate these...
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Fall 2022
Background Intraportal islet transplantation is a suitable method to treat type 1 diabetes. However, this treatment option is limited to a small subpopulation of patients with diabetes. For islet transplantation to be a more sustainable treatment option, major obstacles must be overcome. An...
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Fall 2009
Islet transplantation has the potential to be an effective treatment for patients with type 1 diabetes. However, a shortage of human donor islets and the need for continuous immunosuppressive therapy currently limit this therapy to patients with brittle type 1 diabetes. Neonatal pigs may...