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- 3Intraspinal microstimulation
- 1Dorsal root ganglia
- 1Functional electrical stimulation
- 1Motor unit recruitment
- 1Neuromuscular plasticity
Intraspinal microstimulation (ISMS) is a novel electrical stimulation approach to restore standing and ambulation in people with spinal cord injury. The technique entails inserting an array of microwires into the lumbosacral enlargement of the spinal cord to activate neuronal networks that...
Spinal cord injury is a devastating neurological disorder partially characterized by a loss of motor function below the lesion. The dramatic loss of activity results in muscle atrophy and slow-to-fast transformation of contractile elements, producing smaller, weaker and more fatiguable muscles....
The overall goal of this thesis was to develop a proof-of-principle for a device that might eventually restore walking in people with paraplegia. The thesis consisted of three component technologies each working in conjunction with one another in adult cats. The first component was the...