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Spring 2011

Peake, Kyle

Niemann-Pick Type C (NPC) disease is an autosomal recessive disorder that results in accumulation of unesterified cholesterol in late endosomes/lysosomes (LE/Ls), leading to progressive neurodegeneration and premature death. Microglia are resident immune cells of the central nervous system, which...

1992

Tobin, Bonnie L.

Fall 2021

Sasse, Verena A

Alzheimer’s disease (AD) is a complex and progressive neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ) peptides derived from the proteolytic processing of amyloid precursor protein (APP). The regions primarily affected in AD brains are the hippocampus and...

Fall 2010

Yeung-Yam-Wah, Valerie

Ca2+ is an important mediator of stimulus-secretion coupling in beta cells of the pancreatic islets, which secrete insulin in response to elevation in plasma glucose concentration. I studied the actions of two lipids, arachidonic acid (AA) and cholesterol, on enzymatically-dissociated single...

Fall 2017

Capitanio, Juliana S.

The nucleus is a hallmark of eukaryotic cells. It segregates the genetic material from the cytoplasm. The nucleus is encapsulated by the nuclear envelope which is perforated with nuclear pore complexes (NPCs), macromolecular structures formed by proteins termed nucleoporins (Nups). NPCs and...

Spring 2015

Zhao, Richard

A story-based video game contains many characters. A few are controlled by the player and the majority are virtual characters, controlled by artificial intelligence. In recent years, video game artificial intelligence has developed slower than other aspects of video games, such as graphics,...

Spring 2023

Saravanan, Akash

Many competitive online video games release new characters on a regular basis. Designing these characters requires significant effort on several aspects including art, story, music, and game balance. Thus automating the design of these aspects offers value in saving human effort. This thesis...