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Skip to Search Results- 2Insulin-Resistance
- 1Adolescents
- 1Alzheimers-Disease
- 1Animal-Models
- 1Beta-D-Glucosaminidase
- 1Cardiovascular-Disease
- 1Borthwick, Faye
- 1Chin, Danielle
- 1Debowski, Aleksandra W.
- 1Diane, Abdoulaye
- 1Heth, C.D.
- 1Jacobs, Rene
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Differential expression of hypothalamic metabolic and inflammatory genes in response to short-term calorie restriction in juvenile obese- and lean-prone JCR rats
Download2015
Vine, Donna F., Jacobs, Rene, Pierce, W.D., Heth, C.D., Russell, Jim, Proctor, Spencer D., Borthwick, Faye, Nelson, Randy, Diane, Abdoulaye, Mangat, Rabban
Background: Childhood obesity is an important early predictor of adult obesity and associated comorbidities. Common forms of obesity are underpinned by both environmental and genetic factors. However, the rising prevalence of obesity in genetically stable populations strongly suggests that...
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O-GlcNAcase uses substrate-assisted catalysis Kinetic analysis and development of highly selective mechanism-inspired inhibitors
Download2005
Vocadlo, David J., Whitworth, Garrett E., Macauley, Matthew S., Debowski, Aleksandra W., Chin, Danielle
The post-translational modification of serine and threonine residues of nucleocytoplasmic proteins with 2-acetamido-2-deoxy-d-glucopyranose (GlcNAc) is a reversible process implicated in multiple cellular processes. The enzyme O-GlcNAcase catalyzes the cleavage of β-O-linked GlcNAc (O-GlcNAc)...