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Skip to Search Results- 1Ahmed, Kazi Tanveer
- 1Aroonassala Patten, Shunmoogum
- 1Attia, Karen
- 1Bartusiak, Robert
- 1Bond, David JE
- 1Brewster, Daniel L
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A novel group of zebrafish Class II ADP-ribosylation factors and their potential role in photoreceptor development
DownloadFall 2013
In this study we identified an unknown set of Class II Arf isoforms in zebrafish. Bioinformatics analyses grouped these paralogues into three distinct clades. Using antisense morpholino gene knockdown, we tested the effect of loss of each zebrafish Class II Arf on early development and...
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Analysis of Foxc1 Function During Somite Formation and Chondrogenesis of the Axial Skeleton
DownloadSpring 2018
Development of the axial skeleton in vertebrates begins with the segmentation of the paraxial mesoderm into somites. Somites are transient structures in the embryos that ultimately give rise to the skeletal muscle, dermis, tendons, cartilage, and bony structures of the axial skeleton. Once...
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Aquatic nanotoxicity testing: Insights at the biochemical, cellular, and whole animal levels
DownloadFall 2013
Aquatic organisms are susceptible to waterborne nanoparticles and there is only limited understanding of the mechanisms by which these emerging contaminants affect biological processes. The unique properties of nanomaterials necessitate evaluation of standard toxicity testing techniques to...
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Biochemical and Functional Characterization of Inhibitory Leukocyte Immune-Type Receptors in the Channel Catfish (Ictalurus punctatus)
DownloadSpring 2013
Montgomery, Benjamin Christian Sivert
A balance of intracellular signaling events control immune cell functions. In innate immunity, many of these signals are transmitted by subsets of cell surface proteins known as immunoregulatory receptors. Through their recognition of a diverse array of molecules these receptors effectively...
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Spring 2014
The fine balance struck between life and death is key for the health of all multicellular organisms and therefore the pathways that govern life and death decisions are evolutionarily highly conserved. For example, the human TNF and the Drosophila IMD pathways coordinate signaling elements such...
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Chaperone and Gene Regulatory Roles of SMYD1b during Early Skeletal Muscle Development and Heart Morphogenesis
DownloadFall 2017
Sarcomeres are the basic contractile units that make up the striated muscle of the heart and skeletal muscle. The specification and differentiation of muscle cells and the contractile function of the sarcomere are generally well understood, but how the sarcomere assembles remains largely unknown....
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Spring 2016
Normal eye development requires a complex series of morphological movements and ocular patterning with aberrant eye development resulting in birth defects and retinal dystrophies. Eleven percent of paediatric blindness is caused by microphthalmia (small eyes), anophthalmia (no eyes) and coloboma...
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Fall 2014
Fungal pathogens are recognized by Dectin-1, a pattern recognition receptor expressed on mammalian innate immune cells. Dectin-1 detects β-glucans, which are polymers of glucose that are a main component of the fungal cell wall. While purified, soluble β-glucans have been used in the clinic as...
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Characterizing the role of the endocannabinoid system’s catabolic enzymes FAAH and MAGL in the development of functional sensorimotor activities in zebrafish
DownloadFall 2022
The endocannabinoid system (eCS) plays a critical role in a variety of homeostatic and developmental processes. Generally, the eCS relies on the naturally produced compounds known as endocannabinoids (eCBs), which are lipophilic signaling molecules that interact with cannabinoid receptors to...
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Differential expression of nicotinic acetylcholine receptor subunits is critical for the embryonic development of zebrafish muscle and neuromuscular junction
DownloadSpring 2020
Nicotinic acetylcholine receptors (nAChRs) are ligand gated ion channels primarily expressed on muscle fibers and neurons. They are comprised of five subunits arranged in different stoichiometries. nAChRs expressed at the neurons are comprised of different combinations of α1-10 and β1-4 subunits,...