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Spring 2020
Tabatabaei Dakhili, Seyed Amirhossein
Thousands of transcription factors control the process of gene expression and protein synthesis in the human body. These nuclear proteins are fundamental for healthy organ development, cellular function, immunity and body response to diseases and stress. Mutated, overexpressed, or dysregulated...
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Evaluation of Targeted Selective Inhibitors to Enhance Temozolomide Treatment Sensitivity in Acute Myeloid Leukemia
DownloadSpring 2024
Temozolomide (TMZ) is an alkylating agent with limited activity in acute myeloid leukemia (AML). The DNA repair enzyme O6-methylguanine methyltransferase (MGMT) enhances tumor cell resistance to TMZ. B-cell lymphoma-2 (BCL-2) and mouse double minute 2 homology (MDM2) are proteins involved in AML...
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Spring 2022
Alzheimer’s Disease (AD) is an insidious, progressive neurodegenerative disease responsible for the majority of dementia cases worldwide. Despite extensive research and clinical trials, there are currently no approved treatments that alter the progression of the disease. Treating classic...