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- 4Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 2Graduate and Postdoctoral Studies (GPS), Faculty of
- 2Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 1Pharmacy and Pharmaceutical Sciences, Faculty of
- 1Pharmacy and Pharmaceutical Sciences, Faculty of/Journal Articles (Pharmacy and Pharmaceutical Sciences)
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Development of Novel Models to Study Sub and Post Cellular Uptake of Drugs Following Oral Administration
DownloadFall 2024
Given the numerous benefits of oral administration, this thesis investigates two key phenomena influencing the pharmacokinetics and pharmacodynamics of orally administered active pharmaceutical ingredients (APIs): lysosomal trapping and intestinal lymphatic uptake via chylomicrons, with a...
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Effects of bulky polycyclic aromatic hydrocarbon adducts on DNA replication by exonuclease-deficient T7 and T4 DNA polymerases
Download1998
Day, B. W., Reha-Krantz, L., Shukla, R., Melacrinos, A., Keohavong, P.
Abstract: In vitro DNA replication by exonuclease-deficient T7 DNA polymerase (Sequenase) and an exonuclease deficient T4 DNA polymerase was examined on a 244-nucleotide DNA template treated with three electrophilic polycyclic aromatic hydrocarbon (PAH) metabolites: racemic...
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Spring 2018
The inertial filtration properties of neonatal infant nasal airways are the focus of this thesis. Nasal replicas based on computed tomography (CT) scan images of seven infants between the ages of 5 and 79 days were created using three-dimensional printing. Deposition of inertial sized aerosol...
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2006
Cooper, W., Hogg, M., Reha-Krantz, L., Wallace, S.S.
The kinetics of forming a proper Watson–Crick base pair as well incorporating bases opposite furan, an abasic site analog, have been well characterized for the B Family replicative DNA polymerase from bacteriophage T4. Structural studies of these reactions, however, have only been performed with...
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Molecular cloning, pharmacological characterization and brain mapping of the melanocortin 4 receptor in the goldfish: Involvement in the control of food intake
Download2003
Schioth, H.B., Cerdá-Reverter, J.M., Peter, R.E., Ringholm, A.
We report cloning, pharmacological characterization, tissue distribution, detailed brain mapping, and role in control of food intake of melanocortin 4 receptor in goldfish (gMC4R). The gMC4R protein has 68% identity with the human ortholog and is conserved in important functional domains....
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Optimization of a two-step desolvation method for preparing gelatin nanoparticles and cell uptake studies in 143B osteosarcoma cancer cells
Download2006
Abrams, D., Huang, Y., McQuarrie, S., Roa, W., Chen, H., Löbenberg, R., Azarmi, S., Miller, G. G., Finlay, W. H.
Abstract: PURPOSE: To establish a matrix of parameters to synthesize nanoparticles of different sizes and to investigate the cellular uptake of these nanoparticles by osteosarcoma cancer cells in order to investigate their potential as therapeutic drug-delivery carriers. METHODS: Gelatin A and B...
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Primary structure of a novel gonadotropin-releasing hormone (GnRH) in the brain of a teleost, Pejerrey
Download2001
Somoza, G.M., Rivier, J.E., Fischer, W.H., Park, M.K., Chang, J.P., Craig, A.G., Montaner, A.D., Sherwood, N.M.
The neuropeptide GnRH is the major regulator of reproduction in vertebrates acting as a first signal from the hypothalamus to pituitary gonadotropes. Three GnRH molecular variants were detected in the brain of a fish, pejerrey (Odontesthes bonariensis), using chromatographic and immunological...