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- 1Briney, Bryan
- 1Burton, Dennis R.
- 1Cheng, T. Y.
- 1Cottrell, Christoph A.
- 1Golonka, R.
- 1Hardes, Jennifer J
Exploring the Association between Parental Concern about Vaccine Safety and Incomplete Childhood Immunization: A Multivariate ModelDownload
High levels of immunization coverage are required to maintain control of infectious diseases that previously caused significant illness and death in Canada. However, childhood immunizations have been so successful that many Canadians have never seen the impact of these diseases, with some parents...
Holes in the glycan shield of the native HIV envelope are a target of trimer-elicited neutralizing antibodiesDownload
Hsueh, Jessica, Menis, Sergey, Sanders, Rogier W., Ozorowski, Gabriel, Pauthner, Matthias, Voss, James E., van Gils, Marit J., Torres, Jonathan L., McCoy, Laura E., Ward, Andrew B., Wilson, Ian A., Schief, William R., Macauley, Matthew S., Burton, Dennis R., Cottrell, Christoph A., Messmer, Terrence, Sok, Devin, Briney, Bryan, Kulp, Daniel W.
A major advance in the search for an HIV vaccine has been the development of a near-native Envelope trimer (BG505 SOSIP.664) that can induce robust autologous Tier 2 neutralization. Here, potently neutralizing monoclonal antibodies (nAbs) from rabbits immunized with BG505 SOSIP.664 are shown to...
Hepatitis C virus (HCV) leads to chronic infection in the majority of infected patients presumably due to failure or inefficiency of the immune responses generated. Both antibody and cellular immune responses have been suggested to be important in viral clearance. Non-replicative adenoviral...
Background: Children in care of the child welfare system (‘children in care’) are a vulnerable population who access preventive health services less than children not in care. Objective: To assess immunization coverage of a cohort children who have been in care in Canada and compare it to...
This thesis charts and explores the effects of a basic socio-political logic of English and Canadian case law on assisted dying. It focuses specifically on a problematic paternalism within such law and questions why judicial decisions consistently refuse to recognize so-called ‘compassionate...
In recent years, narratives about various embellished and imaginary risks of vaccination have come under criticism because of their implications for the widespread acceptance of vaccines. Criticisms of these narratives often accompany assumptions that all mainstream health professionals accept,...
I investigated how recent immigrant mothers access and use current vaccine risk communication in their immunization decisions for themselves and their children. To complete this research, I engaged in a community-driven participatory research partnership with the Multi-Cultural Health Brokers...
Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation
Lipids from mycobacteria can be presented to human T cells by group 1 CD1 Ag-presenting molecules (CD1a, CD1b, and CD1c). Group 1 CD1-restricted T cells are activated by lipid Ags presented by myeloid dendritic cells (DCs), after which they generate antibacterial effector functions, including...
The pot calling the kettle black: The extent and type of errors in a computerized immunization registry and by parent report.Download
Background Accurate classification of children’s immunization status is essential for clinical care, administration and evaluation of immunization programs, and vaccine program research. Computerized immunization registries have been proposed as a valuable alternative to provider paper records or...