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Fall 2010

Lim, Aaron Guanliang

Human T-lymphotropic virus type I (HTLV-I) is a persistent human retrovirus characterized by life-long infection and risk of developing HAM/TSP, a progressive neurological and inflammatory disease. Despite extensive studies of HTLV-I, a complete understanding of the viral dynamics has been...

Spring 2018

Lavallee, Celeste M

Neonates with intestinal failure (IF), who must rely on parenteral nutrition (PN) for growth and maintenance of health, are at risk for intestinal failure-associated liver disease (IFALD). In neonates, short bowel syndrome (SBS) as a result of intestinal resection is the most common cause of IF....

Spring 2023

Lopes, Nayara Gabriela Antunes

Prenatal maternal stress (PNMS) is any type of stress that pregnant women and animals experience. It was reported that over 70% of pregnant women experience low to moderate stress, while 6% experience high stress. Growing evidence indicates that PNMS influences maternal and offspring health...

2015

Chakrabarti, Subhadeep, Wu, Jianping

Milk derived tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) have shown promise as anti-hypertensive agents due to their inhibitory effects on angiotensin converting enzyme (ACE). Due to the key inter-related roles of hypertension, chronic inflammation and insulin resistance in the...

Spring 2020

Howlader, Md Amran

The human neuraminidases (NEU1, NEU2, NEU3, and NEU4) are a family of enzymes implicated in pathologies including cancer and diabetes. Our group has developed selective inhibitors for these enzymes that have been employed as tools to understand their biological roles. Several reports have linked...

Fall 2020

Litchfield, Marcus

Positron emission tomography (PET) relies on the use of β+-emitting radionuclide-bearing molecules congregating and decaying at a specific site of interest. Use of these molecules, called radiotracers, which target common tumor characteristics has become a pillar in the diagnosis of cancer and...

Fall 2016

Sarfraz, Muhammad K

Macrophages are the primary cells of innate immunity that provide the first line of defence against any external stimuli. Their phagocytic properties enable them to engulf invading microbes or foreign particles. The phagocytic capability of macrophages plays a major role in interfering with drug...

2012

Hartmann, Martin, Sekirov, Inna, Finlay, B. Brett, Al-Zahrani, Fatimah, Willing, Benjamin P., Ferreira, Rosana B. R., Gill, Navkiran, Antunes, L. Caetano M.

The intestinal microbiota has been found to play a central role in the colonization of Salmonella enterica serovar Typhimurium in the gastrointestinal tract. In this study, we present a novel process through which Salmonella benefit from inflammatory induced changes in the microbiota in order to...

Fall 2013

Iqbal, Summera

The transition period is critical for the health and productivity of dairy cows. Feeding high-grain diets immediately after parturition is necessary to support high milk production. However, high-grain diets are associated with acidic rumen pH and alterations in the composition of rumen...

Fall 2023

Friedman, Timothy N.

The overarching idea of this thesis stemmed from previous work in our lab, where it was noticed that females and males exhibited different disease trajectories in a model of Multiple Sclerosis. Combined with our observation of different outcome metrics for peripheral nociception suggested that...