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Effects of Tripeptide IRW (Ile-Arg-Trp) on metabolism, mitochondrial biogenesis, and lifespan extension
DownloadSpring 2022
Bioactive tripeptide IRW (Ile-Arg-Trp) was initially identified as an ACE (angiotensin-converting enzyme) inhibitory peptide from egg protein ovotransferrin. The pharmacological spectrum of IRW extends towards metabolic boosting and anti-diabetic properties as well. The overall objectives of this...
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Egg-white derived bioactive peptides improve insulin resistance and non-alcoholic fatty liver disease in mice: mechanisms of action
DownloadFall 2023
Zani, Stepheny Carneiro de Campos
Metabolic syndrome is a condition characterized by the presence of multiple co-morbidities including hypertension, dyslipidemia, obesity and hyperglycemia. More recently, non-alcoholic fatty liver disease (NAFLD) has been included in this cluster as the hepatic manifestation of the metabolic...
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Fall 2022
Metabolic syndrome, a major public health challenge, is identified as a collection of impaired glucose metabolism, central obesity, elevated blood pressure and dyslipidemia. It is estimated that approximately 25% of the world’s population has metabolic syndrome. Insulin resistance, a pathologic...
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The Regulatory Roles of Peptide IRW on angiotensin-converting enzyme 2 (ACE2) in High-Fat Diet-Induced Mice and Spontaneously Hypertensive Rats
DownloadFall 2023
Metabolic syndrome (MetS) refers to a cluster of various risk factors commonly associated with cardiovascular diseases (CVDs) and diabetes. Up-regulation of angiotensin-converting enzyme 2 (ACE2), a key member of the renin-angiotensin system (RAS), is generally protective against CVDs and...