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Skip to Search Results- 2Hypothemycin
- 2Polyketides
- 1Acyl carrier protein
- 1Biological Diels-Alder reaction
- 1Biosynthesis
- 1Dehydrocurvularin
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Biosynthetic Studies of Resorcylic Acid Lactones, Hypothemycin, Radicicol, and Dehydrocurvularin
DownloadFall 2013
Fungal polyketides, a vast source for pharmaceutical industries, are biosynthesized by multifunctional iterative polyketide synthases (PKS). The biosynthesis employs complex programming rules, which are currently unresolved. To decode the programming rules, the biosynthesis of three polyketides,...
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Investigations of Fungal Highly Reducing Polyketide Synthases: The Biosyntheses of Lovastatin and Hypothemycin
DownloadFall 2017
Fungal highly reducing polyketide synthases (HR-PKSs) are large, multi-domain enzymes central to the biosynthesis of fungal polyketides. They assemble complex secondary metabolites, called polyketides, through the condensation of two-carbon acetate units and tailoring of the functional groups at...