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Skip to Search Results- 1Ben-Eltriki,Mohamed Ahmed
- 1Botham, Kathleen M.
- 1Cabezas, Manuel C.
- 1Chaudhary, Hetal R
- 1El Sayed, Dalia
- 1Gabr,Raniah Q
- 5Graduate and Postdoctoral Studies (GPS), Faculty of
- 5Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 1Agricultural, Food and Nutritional Science, Department of
- 1Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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Fall 2012
Cardiometabolic syndrome refers to a clustering of several risk factors for cardiovascular disease; obesity and hyperlipidemia are two underlying disorders associated with the syndrome. An often overlooked aspect of these conditions is the effect that they may have on the pharmacokinetics of...
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The effect of oral lipids and lipoproteins on the biodistribution, metabolism and electrocardiographic side-effects of halofantrine
DownloadSpring 2011
In the past, hyperlipidemia (HL) has been shown to affect the pharmacokinetic and pharmacodynamic properties of lipophilic drugs extensively bound to lipoproteins, including halofantrine (HF). The present thesis examined the effect of HL on the biodistribution, metabolism and electrocardiographic...
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The Effects of Elements of Cardiometabolic Syndrome on Metformin Disposition: Obesity and Hyperlipidemia
DownloadFall 2015
The influences of obesity, Roux-en-Y gastric bypass bariatric (RYGB) surgery and hyperlipidemia on metformin pharmacokinetics (PK) were investigated. A sensitive and novel HPLC-UV reverse phase assay method was developed and utilized. Detection and mass characterization for metformin metabolites...
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The effects of hyperlipidemia on the pharmacokinetic and pharmacodynamic aspects of amiodarone and ketoconazole
DownloadFall 2010
The influence of hyperlipidemia on the pharmacodynamic and pharmacokinetic aspects of lipophilic drugs was explored. The antiarrhythmic, amiodarone, and the antifungal, (±)-ketoconazole, were used as model drugs. Experimental hyperlipidemia was induced in rat using poloxamer 407 and two sensitive...
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The poloxamer 407 induced hyperlipidemic rat model and its effect on renal toxicity of calcineurin inhibitors
DownloadFall 2012
The present study characterized poloxamer 407 (P407) induced hyperlipidemia in rats and investigated its effect of on renal toxicity of the immunosuppressants tacrolimus and cyclosporine A. P407 (0.5 or 1 g/kg) was injected in rats and blood samples were collected at different time-points....
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Understanding postprandial inflammation and its relationship to lifestyle behaviour and metabolic diseases
Download2012
Cabezas, Manuel C., Mamo, John C., Proctor, Spencer D., Botham, Kathleen M., Klop, Boudewijn
Postprandial hyperlipidemia with accumulation of remnant lipoproteins is a common metabolic disturbance associated with atherosclerosis and vascular dysfunction, particularly during chronic disease states such as obesity, the metabolic syndrome and, diabetes. Remnant lipoproteins become attached...