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Background Pbx genes encode TALE class homeodomain transcription factors that pattern the developing neural tube, pancreas, and blood. Within the hindbrain, Pbx cooperates with Hox proteins to regulate rhombomere segment identity. Pbx cooperates with Eng to regulate midbrain-hindbrain boundary...
Roles for Transcription Factors and Signaling Pathways in Hindbrain Segmentation and Ventricle MorphogenesisDownload
During development, expression and localization of transcription factors and transcriptional co-regulators must be tightly controlled, and in turn they are required to regulate cellular identity and cellular processes. Often this involves complex interactions with signaling pathways. We are...
The roles of Pbx and Meis TALE-class homeodomain transcription factors in vertebrate neural patterningDownload
One of the major goals of developmental biology is to understand how specialized groups of cells arise from an initially unspecified cell population. The vertebrate hindbrain is transiently segmented along its anterior-posterior axis into lineage-restricted compartments called rhombomeres, making...
Retinoic acid (RA) has a crucial role in embryonic nervous system development - controlling anterior-posterior patterning, neural differentiation, and cell proliferation. During zebrafish embryogenesis, levels of RA are tightly regulated by the combinatorial action of synthesis and degradation...