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- 5Hepatitis C virus
- 1DNA virus
- 1Differentiated hepatocytes
- 1Epigallocatechin gallate
- 1Hepatocytes-like cells
Characterization of the Humoral Immune Response Elicited Against a Prophylactic Vaccine Composed of Recombinant Envelope Glycoproteins from Hepatitis C VirusDownload
A global prophylactic vaccine for Hepatitis C Virus (HCV) remains elusive. The diversity of the virus is a major hurdle; a successful vaccine will need to protect against all 7 HCV genotypes (gt). Our lab is developing a vaccine comprising the two envelope glycoproteins of HCV (E1E2). An...
Differentiation of human embryonic stem cells into hepatocytes and their in vivo application for hepatitis C viral productionDownload
Abstract Introduction: Chronic hepatitis C virus (HCV) infection is a global problem. The World Health Organization estimates that about 170 million individuals around the world are infected with HCV. Chronic HCV has a high rate of morbidity and mortality due to cirrhosis and hepatocellular...
Approximately 70% of patients infected with hepatitis C virus (HCV) develop chronic infection, which has been reported to be due to impaired specific T cell responses. Myeloid dendritic cells (mDCs) are potent antigen-presenting cells that regulate T cell responses, however their role during...
Novel Agents Inhibiting Hepatitis C Virus; Application to Prevention of Re-infection after Liver TransplantationDownload
Recurrent Hepatitis C virus infection drives inferior outcomes experienced by patients undergoing liver transplantation due to HCV-associated liver disease. Existing therapies exhibit increased toxicity, poor efficacy, and profound patient intolerability in the immediate transplantation period....
The Discovery and Characterization of Rigid Amphipathic Fusion Inhibitors (RAFIS), a Novel Class of Broad-Spectrum Antiviral CompoundsDownload
Antiviral drugs targeting viral proteins or their interactions with cellular proteins lead to rapid selection for resistance. Moreover, the number of viral targets is limited. Novel antiviral targets are needed. The unique characteristics of fusion between virion envelopes and cell membranes may...