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Bridging COVID-19-mediated Myocardial Inflammation and the Epicardial Adipose Tissue in Heart Failure: ACE2 Regulation at Center Stage
DownloadFall 2023
ACE2 was discovered as the primary effector enzyme of the protective, counter-regulatory arm of the renin-angiotensin system (RAS). The canonical RAS, comprising the angiotensin-converting enzyme (ACE)/angiotensin II (Ang II)/AT 1 receptor (AT1R) axis, mediates proinflammatory, profibrotic, and...
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Fall 2022
Background The discovery of angiotensin-converting enzyme 2 (ACE2) introduced an alternative protective arm of the renin-angiotensin system (RAS), the ACE2/Angiotensin 1-7 (Ang 1-7)/Mas receptor axis, to counterbalance the more renowned pathogenic angiotensin-converting enzyme (ACE)/Angiotensin...
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Understanding Heart Failure in Patients with Dilated Cardiomyopathy: A Direct Tissue Analysis from Explanted Human Hearts
DownloadFall 2022
Background Chronic heart failure (HF) remains a rising global epidemic that affects both adults and children population. The causes of HF are heterogeneous, and syndromes are often complicated by concomitant disorders such as iron deficiency (ID) and diabetes. Comorbidities not only complicate...