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16R-HETE and 16S-HETE Alter Human Cytochrome P450 1B1 through Transcriptional and Allosteric Mechanism
DownloadFall 2022
Cardiac hypertrophy is a complex anomaly of the heart associated with increased muscle mass and thickening of the cell walls in response to accumulative stress. Although this condition occurs naturally, the prolonged state will progress into heart failure or even cause death. Recent studies have...
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Bridging COVID-19-mediated Myocardial Inflammation and the Epicardial Adipose Tissue in Heart Failure: ACE2 Regulation at Center Stage
DownloadFall 2023
ACE2 was discovered as the primary effector enzyme of the protective, counter-regulatory arm of the renin-angiotensin system (RAS). The canonical RAS, comprising the angiotensin-converting enzyme (ACE)/angiotensin II (Ang II)/AT 1 receptor (AT1R) axis, mediates proinflammatory, profibrotic, and...
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Fall 2011
Despite advances in heart failure (HF), mortality rates remain high and the affected population continues to grow. Improvement in symptomology, and quality of life is noted when exercise is included in the treatment plan. Despite this, exercise adherence is a challenge for people with HF. To...
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Heart Failure Related Outcomes in Patients within a Specialized Clinic-Based Cohort and a Population Level Cohort: Emphasis on Diabetes
DownloadFall 2024
Diabetes mellitus (DM) is a well-established risk factor for adverse prognosis in patients with heart failure (HF). Outcomes in this patient population have not been thoroughly investigated in specialized heart function clinics (HFC). Recently, sodium-glucose cotransporter-2 (SGLT2) inhibitors...
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Spring 2014
Many heart failure (HF) hospital admissions are avoidable with appropriate surveillance and self-care support that HF Clinics can provide. Previous studies conducted vary in approach to surveillance. The goal of this study was to assess the impact of frequency of HF Clinic recall visits on...
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Non-invasive cardiac magnetic resonance imaging techniques for assessment of myocardial fibrosis
DownloadFall 2020
While there may be numerous underlying origins, myocardial fibrosis is a common, unifying finding in various forms of heart disease. Unfortunately, its presence goes beyond simply being a herald of myocardial injury. The alterations in the extracellular space lead to abnormalities in both...
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Spring 2021
Mechanical circulatory support has become a therapeutic option for children with advanced heart failure. This type of support is often used to bridge patients to heart transplantation with approximately a third of all patients listed for transplant requiring some form of mechanical support. While...
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Physical Activity in Association with Prognostic Determinants Across Heart Failure Continuum
DownloadFall 2020
Heart Failure (HF) is a complex syndrome that greatly contributes to declining physical function in older adults and causes a substantial economic burden for health care systems. Older adults at risk of developing HF typically have other comorbidities. In addition, patients with HF often...
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Fall 2014
Cardiac Fatty acids β-oxidation (FAO) markedly increases during maturation and become the major source of energy for the adult heart. However, excessive rates of FAO can compromise cardiac function in obesity, diabetes, and heart failure. Lysine acetylation has recently been identified as a...