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The effects of hyperlipidemia on the pharmacokinetic and pharmacodynamic aspects of amiodarone and ketoconazole
DownloadFall 2010
The influence of hyperlipidemia on the pharmacodynamic and pharmacokinetic aspects of lipophilic drugs was explored. The antiarrhythmic, amiodarone, and the antifungal, (±)-ketoconazole, were used as model drugs. Experimental hyperlipidemia was induced in rat using poloxamer 407 and two sensitive...
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Therapeutic drug monitoring of mycophenolic acid and para-cresol in human plasma and dried blood spots: analytical assay development and validation
DownloadFall 2022
Kidneys are amongst the most transplanted organs in pediatric, adult, and geriatric populations. Post transplantation, the recipients are prescribed a regimen of immunosuppressants to avoid or decrease the chances of graft rejection. Mycophenolic acid (MPA) is one of the widely prescribed...