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Development and Application of Electrospray Ionization Mass Spectrometry (ESI-MS) Methods for Measuring Carbohydrate-Active-Enzyme (CAZyme) Kinetics
DownloadSpring 2023
This thesis focuses on the development of electrospray ionization mass spectrometry (ESI-MS)-based methods for measuring carbohydrate-active enzyme (CAZyme) kinetics and their applications for profiling CAZyme specificity, glycoprotein remodeling and disease diagnosis. Chapter 2 introduces...
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Exploiting bacterial glycosylation machineries for the synthesis of a Lewis antigen-containing glycoprotein
Download2011
Hug, Isabelle, Reiz, Bela, Fentabil, Messele A., Klassen, John S., Whittal, Randy M., Zheng, Blake, Feldman, Mario F.
Glycoproteins constitute a class of compounds of increasing importance for pharmaceutical applications. The manipulation of bacterial protein glycosylation systems from Gram-negative bacteria for the synthesis of recombinant glycoproteins is a promising alternative to the current production...
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Fall 2019
This thesis focuses on the development and application of electrospray ionization mass spectrometry (ESI-MS) based methods for characterizing glycoproteins (GPs) and investigating their interactions with glycan binding proteins (GBPs) and drugs. A multipronged approach was developed to identify...