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Spring 2023
The discontinuous split-gene structure is a core feature of eukaryotic gene architecture and requires pre-mRNA splicing to remove silent intron sequences from the initial pre-mRNA transcript before it becomes a mature mRNA suitable for protein synthesis. Splicing begins with recognition of both...
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Non-viral Gene Delivery of BMP-2 Plasmid from Collagen Based Scaffolds for Bone Regeneration Therapy
DownloadSpring 2021
Significant progress in the field of bone regeneration therapy has been achieved in the last two decades. While regeneration therapies with autogenous, allografts and exogenous grafts are remaining the preferred treatments, the outcomes remained are usually sub-optimal. Gene therapy holds a great...