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Skip to Search Results- 4GM1
- 2Affinity measurement
- 2Cholera toxin
- 2Cooperativity
- 2Electrospray ionization mass spectrometry
- 1Gangliosides
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Measuring positive cooperativity using the direct ESI-MS assay: Cholera toxin B subunit homopentamer binding to GM1 pentasaccharide
Download2014
Kitova, Elena N., Lin, Hong, Klassen, John S.
Direct electrospray ionization mass spectrometry (ESI-MS) assay was used to investigate the stepwise binding of the GM1 pentasaccharide β-D-Galp-(1→3)-β-D-GalpNAc-(1→4)[α-D-Neu5Ac-(2→3)]-β-D-Galp-(1→4)-β-D-Glcp (GM1os) to the cholera toxin B subunit homopentamer (CTB5) and to establish...
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Measuring positive cooperativity using the direct ESI-MS assay: Cholera toxin B subunit homopentamer binding to GM1 pentasaccharide
Download2014
Lin, Hong, Klassen, John S., Kitova, Elena N.
Direct electrospray ionization mass spectrometry (ESI-MS) assay was used to investigate the stepwise binding of the GM1 pentasaccharide β-D-Galp-(1→3)-β-D-GalpNAc-(1→4)[α-D-Neu5Ac-(2→3)]-β-D-Galp-(1→4)-β-D-Glcp (GM1os) to the cholera toxin B subunit homopentamer (CTB5) and to establish...
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Role of gangliosides in extracellular vesicle secretion in wild-type and Huntington's disease cell models
DownloadFall 2020
Gangliosides are sialic acid containing glycosphingolipids highly enriched in the brain that play vital roles in intercellular communication, cell signalling and calcium homeostasis. A decrease in the ganglioside levels in the brain has been associated with several neurodegenerative diseases....
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Therapeutic effects of ganlgioside GM1 and gangliomimetic compounds in multiple models of Huntington disease
DownloadSpring 2016
Huntington disease (HD) is a neurodegenerative disorder that results in motor, cognitive and psychiatric deficits. The disease is caused by the expansion of a polyglutamine stretch in huntingtin (HTT), a ubiquitous protein with unclear functions. The molecular mechanisms underlying...